China and the U.S. are currently the two most important trade partners of Brazil. Brazil is engaged in complex bilateral relations with both countries in political, security, and economic affairs. This chapter is divided into four sections. The first one compares Brazil’s bilateral relations with the U.S. and China by reviewing the developments of their diplomatic relationships in the past decades. The following section discusses how China’s rise may affect U.S. interests in Brazil and its region. The third section analyzes areas in which the competition between the U.S. and China could be positively affected by Brazilian courses of action in foreign policy. Finally, there is an analysis of possible U.S. foreign policy orientations toward Brazil and its region.